Intramolecular ditryptophan crosslinks enforce two types of antiparallel β structures
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چکیده
منابع مشابه
Antiparallel, intramolecular triplex DNA stimulates homologous recombination in human cells.
The DNA motif 5'-AAGGGAGAAXGGGTATAGGGYAAGAGGGAA-3' (named XY32) is an H-palindrome and has been shown to undergo a superhelix-induced, pH-dependent structural transition to H-form (pyrimidine purineo pyrimidine triplex) DNA when X = Y = A (AA32) or X = Y = G (GG32), but when X = A and Y = G (AG32) or X = G and Y = A (GA32), the transition is much more difficult [Mirkin, S. (1987) Nature (London...
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Intramolecular triple helices have been obtained by folding back twice oligonucleotides formed by decamers bound by non-nucleotide linkers: dA10-linker-dA10-linker-dT10 and dA10-linker-dT10-linker-dA10. We have thus prepared two triple helices with forced third strand orientation, respectively antiparallel (apA*A-T) and parallel (pA*A-T) with respect to the adenosine strand of the Watson-Crick ...
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*Center for Structural Biology and Bioinformatics, Laboratory for Structure and Function of Biological Membranes, Faculté des Sciences, Université Libre de Bruxelles, CP 206/2, Blvd. du Triomphe, B-1050 Brussels, Belgium, †Center for the Prevention of Obesity, Cardiovascular Disease and Diabetes, Children’s Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609,...
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has been synthesized as a conformational model for disulfide loops of limited ring size. 'H-nmr studies a t 270 MHz establish the presence of three intramolecular hydrogen bonds involving the Leu, Val, and methylamide NH groups in CDCl,. Evidence for peptide aggregation in CDCl, is also presented. A structural transition involving loosening of the hydrogen bond formed by the Val NH group is obs...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2001
ISSN: 1074-5521
DOI: 10.1016/s1074-5521(01)00077-1